Cefazolin concentrations in bone and synovial fluid.

D J Schurman; H P Hirshman; G Kajiyama; K Moser; D S Burton

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PubMed · 649639

Cefazolin concentrations in bone and synovial fluid.

D J Schurman·H P Hirshman·G Kajiyama·K Moser·D S Burton

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Abstract

A single intravenous dose of one gram of cefazolin was administered prophylactically to forty-eight patients undergoing total joint replacement. The serum half-life of the antibiotic was 1.8 hours, the same value found in normal volunteers. The mean concentration in bone during surgery was 5.7 micrograms per gram of bone. The mean concentration in synovial fluid during surgery was 24.4 micrograms per milliliter of fluid.

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Biological Availability Bone and Bones Cefazolin Cephalosporins Half-Life Humans Injections, Intravenous Joint Prosthesis Postoperative Care Preoperative Care Surgical Wound Infection Synovial Fluid Tourniquets Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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D J Schurman, H P Hirshman, G Kajiyama, K Moser, D S Burton. 1978. Cefazolin concentrations in bone and synovial fluid.. https://pubmed.ncbi.nlm.nih.gov/649639/

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