PubMed · 6497409
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S J Stegman. 1984. Scalp reduction surgery.. https://pubmed.ncbi.nlm.nih.gov/6497409/
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An 8-year-old castrated male Paint Horse was referred because of generalized pruritus, alopecia, and intermittent fever. Results of gross evaluation of the skin and microscopic evaluation of skin scrapings were inconclusive. Histologic examination of skin biopsy specimens revealed vasculitis. The horse had persistent hypercalcemia; therefore, lymphosarcoma was considered a possibility. Ultrasonography revealed hypoechoic nodules within the parenchyma of the spleen and liver. Results of microscopic evaluation of an aspirate from a splenic nodule were suggestive of lymphosarcoma. The condition of the horse deteriorated, and it was subsequently euthanatized. Postmortem examination revealed diffuse lymphoma. In human beings, generalized pruritus may be an indication of serious internal disease, including malignancy. Paraneoplastic pruritus is most common in patients with Hodgkin's lymphoma but can also develop in patients with non-Hodgkin's lymphoma, leukemia, or a solid neoplasm. Lymphoma should be considered in the differential diagnoses when examining horses with generalized pruritus for which another cause cannot be identified.
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In recent years numerous molecular biological discoveries enlightened the various steps of the neoplastic transformation. Based on new targets, this development made it possible to synthetize new tumour inhibitory substances. Among them taxanes capable to block depolymerization of tubulin--which is an essential molecule in cell division--play an important role. Docetaxel (Taxotere) belongs to this group and is an active drug in the treatment of breast cancer. Moreover, platinum-resistant tumours may also respond to the therapy. It is important to note that even visceral (hepatic) metastases may express chemosensitivity. Results of combination chemotherapy seem to be also promising. The antitumour effect of Taxotere in NSCLC and other malignant neoplasms in under investigation. The toxicity of Taxotere may be successfully reduced by premedication of steroids. The necessary protective measures render the Taxotere therapy safe and of being perspectivistic.