Liver function and medroxyprogesterone acetate elimination in man.

A Rautio

Home/Archive/PubMed

PubMed · 6498308

Liver function and medroxyprogesterone acetate elimination in man.

A Rautio

View original source ↗Export metadata ↓

Abstract

Medroxyprogesterone acetate (MPA) elimination rate was investigated in 25 patients with primary biliary cirrhosis, alcoholic cirrhosis and fatty liver. The serum and urine concentrations of MPA were measured by RIA after a single oral administration of the drug. Biochemical liver tests and antipyrine kinetics were determined as indicators of the liver function. The antipyrine test, a reflector of the activity of hepatic drug-metabolizing enzyme system, was impaired only in alcoholics. The results demonstrate that the elimination rate of MPA is reduced in subjects with alcoholic cirrhosis, whereas the values of the patients with fatty liver and primary biliary cirrhosis are in the normal range. The findings show that the MPA elimination is impaired only in cases with far advanced liver disease.

Explore related subjects

Antipyrine Fatty Liver Female Humans Liver Liver Cirrhosis, Alcoholic Liver Cirrhosis, Biliary Liver Diseases Liver Function Tests Male Medroxyprogesterone Comparative Study Journal Article Research Support, Non-U.S. Gov't

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

A Rautio. 1984. Liver function and medroxyprogesterone acetate elimination in man.. https://pubmed.ncbi.nlm.nih.gov/6498308/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Silicone rod extraction of pharmaceuticals from water.

Silicone elastomer (in the form of a flexible rod) is one of the materials currently tested for use in analytical extraction techniques and passive sampling devices. We investigated the applicability of this material for the enrichment of selected polar pharmaceuticals (antipyrine, carbamazepine, diclofenac, ibuprofen, bezafibrate) from water. Time-resolved batch extraction tests (up to five weeks in duration) were performed in stirred water samples ( approximately 0.5 L) with 2-cm-long silicone rod pieces. After re-extraction of trapped compounds with methanol, analysis was performed using liquid chromatography coupled with mass spectrometry. Distribution equilibrium was reached after a test duration of seven days. The silicone rod/water partition coefficients of the investigated pharmaceuticals range from 4 (antipyrine) to 1250 (diclofenac), and are related to the hydrophobicity of the compound. Enrichment of these pharmaceuticals in the silicone rod is lower than for other compound classes (chlorinated and polycyclic hydrocarbons).

Antipyrine↗

PubMed2006

Modeling seasonal redox dynamics and the corresponding fate of the pharmaceutical residue phenazone during artificial recharge of groundwater.

Reactive multicomponent transport modeling was used to investigate and quantify the factors that affect redox zonation and the fate of the pharmaceutical residue phenazone during artificial recharge of groundwater at an infiltration site in Berlin, Germany. The calibrated model and the corresponding sensitivity analysis demonstrated thattemporal and spatial redox zonation at the study site was driven by seasonally changing, temperature-dependent organic matter degradation rates. Breakthrough of phenazone at monitoring wells occurred primarily during the warmer summer months, when anaerobic conditions developed. Assuming a redox-sensitive phenazone degradation behavior the model results provided an excellent agreement between simulated and measured phenazone concentrations. Therefore, the fate of phenazone was shown to be indirectly controlled by the infiltration water temperature through its effect on the aquifer's redox conditions. Other factors such as variable residence times appeared to be of less importance.

Antipyrine↗

PubMed2006

Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base.

We synthesized various 3-methyl-1-phenyl-5-pyrazolone (edaravone) derivatives and evaluated their oxidation potential and hydroxyl radical scavenging activity. It was found 3-methyl-1-(pyridin-2-yl)-5-pyrazolone had a much higher ability to scavenge the radical than did edaravone itself. Its efficient radical scavenging activity was assumed to be due to the increase of its anion form, an active form, by a hydrogen-bonded intramolecular base.

Antipyrine↗