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[Fibronectin].

E Klar·D L Heene
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Abstract

Fibronectin is a dimeric glycoprotein with a molecular weight of 440,000. It is a soluble constituent of plasma and other body fluids and a fibrillar matrix protein of connective tissue. The two components are structurally similar and convertible. The possibility of multiple molecular interactions gives rise to a variety of biological functions. The regulation of cell growth and the reduced shedding of fibronectin from malignant cells raises the question as to whether fibronectin is valid as a tumour marker. In wound healing and chronic inflammation fibronectin serves as a scaffold for the formation of collagen. As opsonic protein it maintains reticuloendothelial function. Especially in shock, fibronectin may become the limiting factor of unspecific host defence mechanisms. The value of a substitution therapy will be discussed.

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AnimalsArteriosclerosisArthritis, RheumatoidChemical PhenomenaChemistryCollagen DiseasesCryoglobulinemiaDisseminated Intravascular CoagulationFibronectinsHumansMononuclear Phagocyte SystemNeoplasmsPhagocytosisShockWound HealingEnglish AbstractJournal Article

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E Klar, D L Heene. 1984-10-15. [Fibronectin].. https://doi.org/10.1007/bf01728426

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