The colchicine experimental epileptic focus: an intracellular study.

A F Reynolds; J C Oakley

doi:10.1016/0006-8993(84)90126-4

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The colchicine experimental epileptic focus: an intracellular study.

A F Reynolds·J C Oakley

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Abstract

A new experimental epileptic focus is described in which colchicine is topically applied to neocortex. Stable epileptiform discharges developed, with bursts of action potentials, coincident with the surface epileptiform events. There were depolarizing and hyperpolarizing neuronal potentials and glial depolarizations concomitantly with the surface epileptic spikes.

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Animals Cerebral Cortex Colchicine Convulsants Electroencephalography Epilepsy Membrane Potentials Neuroglia Neurons Rats Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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A F Reynolds, J C Oakley. 1984-11-26. The colchicine experimental epileptic focus: an intracellular study.. https://doi.org/10.1016/0006-8993(84)90126-4

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