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Vitamin E improves cell-mediated immunity in the burned mouse: a preliminary study.

C Rundus·V M Peterson·R Zapata-Sirvent·J Hansbrough·W A Robinson
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Abstract

Profound immunosuppression occurs after major burn injuries. The ability of vitamin E to prevent post-burn immunosuppression was tested in mice using ear swelling in response to a challenge with 2,4-dinitrofluorobenzene (DNFB) as an in vivo measure of cell-mediated immunity (CMI). Vitamin E was administered to burned mice every other day for 14 days by either the topical or intraperitoneal route. Dimethyl sulphoxide (DMSO) was compared to white petroleum jelly (VAS) as a vehicle for topically administered vitamin E. Mean CMI +/- the standard error of the mean (SEM) was depressed to 55 +/- 4 per cent of normal control in untreated burned mice. Treatment with either parenteral vitamin E in corn oil or topical vitamin E in DMSO improved CMI dramatically compared to burned controls (P less than 0.005) while vitamin E in VAS had a less beneficial effect on CMI (P less than 0.05). We conclude that vitamin E is an effective immunomodulator in burned mice.

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Administration, TopicalAnimalsBurnsFemaleImmunity, CellularMicePrognosisTocopherolsVitamin EJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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C Rundus, V M Peterson, R Zapata-Sirvent, J Hansbrough, W A Robinson. 1984. Vitamin E improves cell-mediated immunity in the burned mouse: a preliminary study.. https://doi.org/10.1016/0305-4179(84)90155-4

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