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PubMed · 6511524

Multiple primary squamous cell carcinomas in the upper digestive tract.

P J Fitzpatrick·B S Tepperman·G deBoer
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Abstract

Multiple squamous cell carcinomas are common and patients carry a constant and excessive risk of developing a new cancer at any time (13-21 X the normal). Among 6,203 cases of primary squamous carcinoma of the upper digestive tract, 648 patients (10.4%) developed two or more independent tumors. Altogether, 761 additional malignancies were observed, with up to five cancers being seen in individual patients. There were 279 patients with a prior or synchronous cancer and 409 patients who developed 462 metachronous tumors. There was a substantial risk for developing a second primary cancer in the upper aerodigestive tract. Overall the observed to expected ratio was 2.48, specifically 2.32 for males and 2.89 for females.

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Carcinoma, Squamous CellEsophageal NeoplasmsFemaleHumansMaleMiddle AgedMouth NeoplasmsNeoplasms, Multiple PrimaryPharyngeal NeoplasmsRiskTime FactorsJournal Article

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P J Fitzpatrick, B S Tepperman, G deBoer. 1984. Multiple primary squamous cell carcinomas in the upper digestive tract.. https://doi.org/10.1016/0360-3016(84)90233-5

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