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Improved competitive indicator methods for the study of alpha-cyclodextrin complexes.

D D Pendergast·K A Connors
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Abstract

The competitive indicator method for studying molecular complexes is extended to systems forming 1:1 (SL) and 1:2 (SL2) complexes of substrate (S) and ligand (L). A modification is described for slightly soluble substrates, in which the presence of solid substrate establishes a constant concentration of uncomplexed substrate. These methods are applied to complexes of alpha-cyclodextrin with some aromatic substrates, with methyl orange as the indicator in acid solution; nitrazine yellow is introduced as an indicator for these studies in basic solution.

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Chemical PhenomenaChemistryCyclodextrinsDextrinsDrug StabilityIndicators and ReagentsPotentiometrySolubilitySpectrophotometryStarchalpha-CyclodextrinsJournal ArticleResearch Support, Non-U.S. Gov't

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D D Pendergast, K A Connors. 1984. Improved competitive indicator methods for the study of alpha-cyclodextrin complexes.. https://doi.org/10.1002/jps.2600731230

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