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Acute infections with Giardia lamblia and rotavirus decrease intestinal permeability to low-molecular weight polyethylene glycols (PEG 400).

R Serrander·K E Magnusson·T Sundqvist
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Abstract

The passive intestinal permeability of patients seeking care for acute diarrhoea was investigated with a liquid meal containing differently sized, low-molecular weight polyethylene glycols (PEG 400; mol. wt. 282-590). The subjects suffered from acute infections caused either by Giardia lamblia or rotavirus. The patients were studied during infection and 3-4 weeks later when they had recovered clinically. It was found that both giardia and rotavirus infections were associated with decreased 6-h urinary recovery of the PEG molecules, particularly of the larger molecular weight species. After the infection, the permeability properties returned towards normal values. The results show that the permeability and the absorptive capacity is altered in patients with acute Giardia lamblia and rotavirus infections which could be important in relation to chronic infections and malnutrition attributed to these organisms.

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Acute DiseaseAdultDiarrheaFemaleGiardiasisHumansIntestinal AbsorptionMaleMiddle AgedPermeabilityPolyethylene GlycolsRotavirus InfectionsJournal ArticleResearch Support, Non-U.S. Gov't

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R Serrander, K E Magnusson, T Sundqvist. 1984. Acute infections with Giardia lamblia and rotavirus decrease intestinal permeability to low-molecular weight polyethylene glycols (PEG 400).. https://doi.org/10.3109/00365548409073958

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Acute spermatic cord torsion alters the microcirculation of the contralateral testis.

PURPOSE: The purpose of this study was to characterize the hemodynamic changes in the contralateral testis during acute spermatic cord torsion in anesthetized rats. MATERIALS AND METHODS: We used videomicroscopy to examine the microcirculation of the contralateral testis following acute torsion. Specifically, we examined the effect on vasomotion, a rhythmic dilation and constriction of the arterioles that is involved in fluid and nutrient exchange and modulation of local vascular resistance. In a separate set of experiments, blood flow in the contralateral internal spermatic artery was measured with an ultrasonic flow probe during acute torsion. RESULTS: Following 720 degrees torsion, the amplitude of vasomotion in the contralateral testis increased 121% (29.0 +/- 3.9% versus 13.0 +/- 1.7%) compared with controls. Blood flow in the contralateral internal spermatic artery decreased 43% after 2 hours' torsion. CONCLUSIONS: Acute spermatic cord torsion altered the microcirculation by increasing the amplitude of vasomotion and decreased total blood flow to the opposite testis. Because the hydraulic resistance of a blood vessel exhibiting vasomotion is always less than a vessel with the same average but static diameter, the observed microcirculatory changes may be an adaptive response to preserve local flow in the presence of decreased total flow. The long-term consequences of these changes in the microcirculation may affect testicular function and ultimately fertility.

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