Structure-activity relationships for dermorphin-related tetrapeptides.

G Sarto; P A Borea; S Salvadori; R Tomatis

doi:10.1159/000137992

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Structure-activity relationships for dermorphin-related tetrapeptides.

G Sarto·P A Borea·S Salvadori·R Tomatis

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Abstract

The opiate-like activity of six newly synthesized dermorphin-related tetrapeptides was determined in guinea pig ileum, mouse vas deferens and mouse tail-flick tests. Naloxone was a powerful antagonist of all compounds. Moreover, the biological activities of the compounds under examination were correlated in a statistically significant way to the lipophilic character of the C-terminal substituents and to an indicator variable taking into account the presence of an amidic group at the C-terminus.

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Animals Chemical Phenomena Chemistry, Physical Guinea Pigs Ileum In Vitro Techniques Male Mice Muscle, Smooth Narcotics Oligopeptides Opioid Peptides Reaction Time Structure-Activity Relationship Tail Vas Deferens Journal Article Research Support, Non-U.S. Gov't

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G Sarto, P A Borea, S Salvadori, R Tomatis. 1984. Structure-activity relationships for dermorphin-related tetrapeptides.. https://doi.org/10.1159/000137992

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