Acetylcholine sensitivity in replicating satellite cells.

F Eusebi; M Molinaro

doi:10.1002/mus.880070613

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PubMed · 6543903

Acetylcholine sensitivity in replicating satellite cells.

F Eusebi·M Molinaro

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Abstract

Mononucleate myogenic cells lying within skeletal muscle fiber endomysium, the so-called satellite cells (SC), isolated from adult leg muscle of normal or dystrophic mice were studied by electrophysiological techniques. Normal SC responded to iontophoretic acetylcholine (ACh) by depolarization even during the replicative phase. Acetylcholine sensitivity increased after cell fusion. Replicating SC from dystrophic muscle did not exhibit any sensitivity to ACh, and neither did embryonic myoblasts.

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Acetylcholine Action Potentials Animals Cell Division Cell Fusion Cells, Cultured Electrophysiology Iontophoresis Membrane Potentials Mice Mice, Inbred C57BL Muscles Muscular Dystrophy, Animal Journal Article Research Support, Non-U.S. Gov't

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F Eusebi, M Molinaro. Acetylcholine sensitivity in replicating satellite cells.. https://doi.org/10.1002/mus.880070613

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