Vitamin E, physical exercise and tissue oxidative damage.

A T Quintanilha; L Packer

doi:10.1002/9780470720820.ch5

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Vitamin E, physical exercise and tissue oxidative damage.

A T Quintanilha·L Packer

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Abstract

Oxidative damage and the role of antioxidants and prooxidants in aerobic metabolism is of great current interest; it spans areas of research such as carcinogenesis, ageing, toxicology and nutrition. We have used Bantin-Kingman female rats for both in vivo and in vitro studies. In these animals we have altered the levels of all-rac-alpha-tocopherol (vitamin E) by dietary means and have used physical exercise and visible light exposure to alter oxidative stress. Our results show a progressive and specific increase in the susceptibility of many subcellular membranes to oxidative damage with increasing levels of vitamin E deficiency and/or physical stress. In addition, endurance training raised the levels of antioxidative enzymic pathways in both skeletal and cardiac muscle.

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Animals Antioxidants Female Intracellular Membranes Lipid Peroxides Liver Muscles Physical Endurance Physical Exertion Rats Vitamin E Vitamin E Deficiency Comparative Study Journal Article Research Support, Non-U.S. Gov't

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A T Quintanilha, L Packer. 1983. Vitamin E, physical exercise and tissue oxidative damage.. https://doi.org/10.1002/9780470720820.ch5

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