PubMed · 6574544
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D J Kupfer, A J Rush. 1983. Recommendations for depression publications.. https://doi.org/10.1016/0165-1781(83)90068-9
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Indications, efficacy and side-effects of the selective serotonin reuptake inhibitors (SSRI) have now been investigated in numerous studies of varying quality. In the case of some disorders, SSRI have been shown to produce a very positive response-for example compulsive disorders and seasonal winter depression, so-called. In view of their effectiveness, SSRI are now considered first-line drugs for these indications. With respect to other disorders, SSRI are recommended because of their favorable side-effect profile. In further indications the efficacy reported in individual studies need further corroboration. Differences between individual SSRI, which mainly concern kinetics, are described.
The purpose of this study was to compare the personality characteristics of patients with non-psychotic, major depression, seasonal subtype (SAD) to patients with non-psychotic, major depression, without seasonality (non-SAD). The patients were consecutive referrals to a university-affiliated mood disorders outpatient clinic. The personality characteristics were assessed using the five-factor model of personality (FFM) as measured by the revised NEO Personality Inventory (NEO PI-R). Patients were assessed during the acute depressive episode. Controlling for severity of depression, differences were found on only one of the five dimensions, with the SAD patients (n = 43) scoring significantly higher on the Openness dimension than non-SAD patients (n = 57). Based on these results we infer SAD patients may represent a psychologically distinct subgroup of depressed patients-more imaginative, more emotionally sensitive and likely to entertain unconventional ideas than non-SAD patients. This personality constellation may explain why individuals with SAD are more sensitive to and may amplify the mild dysphoria typically associated with winter months.