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A general model for disease-marker association.

N Risch
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Abstract

A general model for analysing disease-marker associations from a random sample of patients and controls is given, assuming an arbitrary number of marker and disease susceptibility alleles. A method for testing the goodness-of-fit of various disease susceptibility models to the observed distribution of genotypes at the marker locus in patient and control samples is given. The method is demonstrated using a recently published data set on type I diabetes.

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Diabetes MellitusGenetic MarkersGenotypeHumansModels, GeneticJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

N Risch. 1983. A general model for disease-marker association.. https://doi.org/10.1111/j.1469-1809.1983.tb00992.x

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