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PubMed · 6583705

Chaotic behavior in dopamine neurodynamics.

R King·J D Barchas·B A Huberman
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Abstract

We report the results of the dynamics of a model of the central dopaminergic neuronal system. In particular, for certain values of a parameter k, which monitors the efficacy of dopamine at the postsynaptic receptor, chaotic solutions of the dynamical equations appear--a prediction that correlates with the observed increased variability in behavior among schizophrenics, the rapid fluctuations in motor activity among Parkinsonian patients treated chronically with L-dopa, and the lability of mood in some patients with an affective disorder. Moreover our hypothesis offers specific results concerning the appearance or disappearance of erratic solutions as a function of k and the external input to the dopamine neuronal system.

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BrainDopamineHumansMathematicsModels, NeurologicalModels, PsychologicalReceptors, DopamineSchizophreniaJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R King, J D Barchas, B A Huberman. 1984. Chaotic behavior in dopamine neurodynamics.. https://doi.org/10.1073/pnas.81.4.1244

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