PubMed · 6593051
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C Lawrence. 1984. Testing for memory disorder.. https://doi.org/10.3109/00048678409161292
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The consumption of alcohol and other addictive drugs is quite low in Norway compared with other European countries. Nevertheless, many will experience some of the various drug effects on the brain. Alcohol, the legal substance, is responsible for most drug-related neurological effects in Norway. Alcohol use results in a variety of different effects in different parts of the central nervous system. Headache and alcohol withdrawal symptoms are frequent complaints, and atrophy of the cerebellar vermis and Wernicke Korsakoff syndrome often result in chronic sequelae. Most other drugs cause less structural damage to the nervous system than alcohol does. Clinical findings, pathogenetic mechanisms and treatment of some drug-related neurological disorders are discussed.
Thiamine deficiency (TD) in rats produces lesions similar to those found in humans suffering from Wernicke's encephalopathy, an organic mental disorder associated with alcoholism. Male Sprague-Dawley rats (n = 29) were deprived of thiamine via a regimen of thiamine-deficient chow and daily intraperitoneal injections of the thiamine antagonist pyrithiamine hydrobromide. Spectra were obtained by using the STEAM sequence. No significant change occurred in the ratio of Cr/NAA, while the ratio of Cho/NAA declined significantly (60 +/- 11%) on Day 14. Eleven rats received intraperitoneal injections of thiamine hydrochloride at the end of 12 days, and dose-dependent recovery in Cho/NAA was observed.