A thymocyte-activating factor derived from glomerular mesangial cells.

D H Lovett; J L Ryan; R B Sterzel

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PubMed · 6601138

A thymocyte-activating factor derived from glomerular mesangial cells.

D H Lovett·J L Ryan·R B Sterzel

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Abstract

The glomerular mesangium is centrally involved in immune-mediated glomerulonephritis. The mesangial cell is a mesenchyme-derived multipotential vascular pericyte, which shares several properties with macrophages. Cultured, proliferating rat mesangial cells produce a factor, mesangial cell-derived thymocyte-activating factor (MC-TAF), which physicochemically and biologically closely resembles macrophage interleukin 1. MC-TAF is heat labile, of low m.w. (approximately 15,000), and adheres to anion exchangers. MC-TAF acts to augment lectin-induced thymocyte proliferation and enhances peripheral lymphocyte production of interleukin 2. These findings suggest that a mesangial cell cytokine may interact with the cellular immune system in an antigenically nonspecific fashion to modulate immune responses in glomerular disease.

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Animals Cells, Cultured Chemical Phenomena Chemistry, Physical Female Glomerulonephritis Interleukin-1 Kidney Glomerulus Lymphocyte Activation Macrophages Male Mice Mice, Inbred C3H Rats Rats, Inbred Strains T-Lymphocytes Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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D H Lovett, J L Ryan, R B Sterzel. 1983. A thymocyte-activating factor derived from glomerular mesangial cells.. https://pubmed.ncbi.nlm.nih.gov/6601138/

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