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USP dissolution III: semilogarithmic dissolution patterns of tablets in rotating-basket assemblies.

J T Carstensen·J L Wright·K Blessel·J Sheridan
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Abstract

The dissolution of a rapidly soluble, finely subdivided substance in a directly compressed tablet and in a wet granulated tablet was treated experimentally and compared with previous theoretical models. The dissolution curves were sigmoid with a semilogarithmic tail when concentration was plotted versus time. As predicted, the slope of the semilogarithmic plots were related to the disintegration decay constant for tablet erosion in the basket.

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Models, ChemicalPharmacopoeias as TopicSolubilityTabletsTechnology, PharmaceuticalUnited StatesJournal Article

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J T Carstensen, J L Wright, K Blessel, J Sheridan. 1978. USP dissolution III: semilogarithmic dissolution patterns of tablets in rotating-basket assemblies.. https://doi.org/10.1002/jps.2600670730

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