PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 6606470

Neutrophil function and HLA-B27.

H Repo·M Leirisalo·P Koivuranta·T Osterman·U Kiistala·C G Gahmberg·H Vapaatalo·A Tiilikainen·O Laitinen
View original source ↗Export metadata ↓

Abstract

The pathogenesis of HLA-B27 linked diseases, including reactive enteroarthritides, is not known. Differences in immune response, cross-reaction between microbial antigens and host cell structures, attachment of microbial components on the host cell surfaces with subsequent autoimmune reaction, and inflammatory responsiveness of the host may be involved. In this contribution we present evidence to show that HLA-B27 positive subjects may be prone to an exaggerated inflammatory response, as compared with HLA-B27 negative subjects.

Explore related subjects

Arthritis, InfectiousHLA AntigensHLA-B27 AntigenHumansNeutrophilsYersinia InfectionsJournal ArticleResearch Support, Non-U.S. Gov't

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

H Repo, M Leirisalo, P Koivuranta, T Osterman, U Kiistala, C G Gahmberg, H Vapaatalo, A Tiilikainen, O Laitinen. 1983. Neutrophil function and HLA-B27.. https://doi.org/10.1093/rheumatology%2Fxxii.suppl_2.168

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Disseminated gonococcal infection presenting as vasculitis: a case report.

A 50-year-old man with alcoholic liver disease presented with fever, tenosynovitis, polyarthritis and a vasculitic rash on the hands and feet for 4 days. He had neutrophilia and raised inflammatory markers. He had no history of sore throat, urethral discharge or travel abroad. His initial blood cultures were negative, and he was treated for vasculitis with steroids. The rash and arthritis seemed to improve initially, but he had another episode of fever. Repeat blood cultures grew Neisseria gonorrhoeae,and he received intravenous ceftriaxone followed by oral ciprofloxacin. He had marked improvement in rash, tenosynovitis and arthritis, and the fever dropped. He also had chlamydial urethritis and received azithromycin. The presentation of disseminated gonococcal infection after a presumptive episode of asymptomatic urethral gonorrhoea is highlighted.

Arthritis, Infectious↗