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PubMed · 6606579

Serum immunoglobulin and complement alterations in interstitial cystitis.

J Mattila·A Harmoinen·O Hällström
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Abstract

Sera from 41 patients with interstitial cystitis were tested for immunoglobulins (IgA, G, M), complement components (C1q, C3, C4) and for C1-esterase inhibitor. There was a statistically highly significant depletion of the serum levels of complement component C4 (p less than 0.001) and immunoglobulin G was markedly elevated (p less than 0.001). Our results suggest the classical pathway activation of the complement system and support the possibility that a chronic local immunological process is involved in the pathogenesis of the disease.

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Complement Activating EnzymesComplement C1qComplement C4Complement Pathway, ClassicalComplement System ProteinsCystitisFemaleHumansImmunoglobulin GImmunoglobulinsMaleMiddle AgedJournal Article

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J Mattila, A Harmoinen, O Hällström. 1983. Serum immunoglobulin and complement alterations in interstitial cystitis.. https://doi.org/10.1159/000474122

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