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Evidence for clonal evolution in pre-B-cell leukaemia.

M Abromowitch·D L Williams·S L Melvin·S Stass
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Abstract

This case study provides evidence for clonal evolution in pre-B-cell leukaemia. At diagnosis, the lymphoblasts from a 3-year-old boy were morphologically subtyped as L1 (French-American-British classification). Their immunophenotype was CALLA+, CIgM+, SIg-, TdT+, and the karyotype was pseudodiploid with a 1;19 translocation. Striking shifts were apparent when the child relapsed 16 months later. The morphologic subtype had changed to L3, CALLA and TdT had disappeared, and a consistent karyotype was lacking. The modal chromosome number had increased through clonal evolution to 85, the 1;19 translocation was retained, and a new marker, a 14q+ (partial duplication) appeared and was present in a majority of cells. These cytogenetic findings are characteristic of a transforming state. However, despite the loss of TdT, the appearance of classic L3 morphology and the acquisition of a 14q+ marker, the cells retained a predominantly pre-B phenotype.

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Antigens, NeoplasmAntigens, SurfaceB-LymphocytesBone MarrowChild, PreschoolChromosome AberrationsHumansKaryotypingLeukemia, LymphoidMaleCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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BibTeXRIS

M Abromowitch, D L Williams, S L Melvin, S Stass. 1984. Evidence for clonal evolution in pre-B-cell leukaemia.. https://doi.org/10.1111/j.1365-2141.1984.tb03971.x

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