Decrease of intracellular chloride activity by furosemide in frog retinal pigment epithelium.

M Wiederholt; J A Zadunaisky

doi:10.3109/02713688409003071

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Decrease of intracellular chloride activity by furosemide in frog retinal pigment epithelium.

M Wiederholt·J A Zadunaisky

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Abstract

We found that intracellular chloride activity in frog retinal pigment epithelium (RPE) was significantly higher than predicted from the equilibrium distribution across the cell membranes. When transepithelial chloride transport was inhibited by furosemide intracellular chloride activity decreased and approached electrochemical equilibrium. These data indicate that RPE possesses an active, furosemide-sensitive chloride transport across the apical membrane.

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Animals Biological Transport, Active Chlorides Furosemide Membrane Potentials Pigment Epithelium of Eye Rana catesbeiana Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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M Wiederholt, J A Zadunaisky. 1984. Decrease of intracellular chloride activity by furosemide in frog retinal pigment epithelium.. https://doi.org/10.3109/02713688409003071

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