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Does pyruvate prevent acrylamide neurotoxicity? Implications for disease pathogenesis.

A B Sterman·D J Panasci·W Persons
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Abstract

We used the prototype environmental neurotoxin, acrylamide monomer, to evaluate the hypothesis that neurotoxin-induced nerve fiber degeneration results from inactivation of axonal glycolytic enzymes. Treating intoxicated rats with sodium pyruvate, we hypothesized, would bypass the putative neurotoxin-induced blockade in glycolysis, thus ameliorating neurobehavioral and morphologic measures of neurotoxicity. After establishing that pyruvate itself did not affect behavior, we examined its effects on acrylamide-intoxicated animals. Pyruvate treatment had a significant effect on only one of eight neurobehavioral measures, though others showed similar trends. A morphologic observation of lumbar dorsal root ganglion cell bodies and peripheral nerves failed to show an effect of pyruvate. Those results suggested that inactivation of glycolytic enzymes alone is not a sufficient explanation of pathogenesis.

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AcrylamidesAnimalsBehavior, AnimalMaleNerve DegenerationNervous System DiseasesPyruvatesRatsRats, Inbred StrainsComparative StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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A B Sterman, D J Panasci, W Persons. 1983. Does pyruvate prevent acrylamide neurotoxicity? Implications for disease pathogenesis.. https://doi.org/10.1016/0014-4886(83)90250-9

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