PubMed · 6635367
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Y Inagaki, T Saito, M Shimizu. 1983. [Nuclear stethoscope].. https://pubmed.ncbi.nlm.nih.gov/6635367/
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OBJECTIVE: This study inquired into the relationship between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and coronary heart disease. METHODS: By polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP), MTHFR 677C-->T mutation was detected in 79 healthy controls and 69 patients with coronary heart disease. RESULTS: The frequency of MTHFR variant V677 of patients was significantly higher than that of healthy controls (P<0.01). CONCLUSION: This study demonstrated that MTHFR gene V677 mutation was probably one of the genetic risk factors of coronary heart disease and this provided a new basis for exploring the relevant pathogenesis.
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