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PubMed · 6638694

Gentamicin-induced hypomagnesemia.

C K Finton·S Bjorkland·G P Zaloga·D E Uddin·B Chernow
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Abstract

There have been several case reports of hypomagnesemia associated with gentamicin therapy. A cause and effect relationship between gentamicin and hypomagnesemia has been difficult to establish in these cases due to: 1) large doses of gentamicin; 2) concomitant administration of other antibiotics and cytotoxic agents; 3) failure to monitor drug levels; and 4) poor oral intake. To test for a direct cause and effect relationship and to determine the frequency of gentamicin-induced hypomagnesemia, we administered the drug for 10 days to six healthy, well-fed, subhuman primates. Five of the six animals developed a mean decrease in serum magnesium of 0.34 mg/dl (P = 0.03) after 10 days of therapy. Four of the five had levels in the frankly hypomagnesemic range (less than 1.4 mg/dl). Urine magnesium values were inappropriately elevated in relation to serum magnesium concentrations. It is concluded that gentamicin-induced hypomagnesemia may occur more commonly than has been previously appreciated. Serial monitoring of serum magnesium in patients receiving gentamicin is recommended.

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AnimalsDose-Response Relationship, DrugFemaleGentamicinsMagnesium DeficiencyPapioJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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C K Finton, S Bjorkland, G P Zaloga, D E Uddin, B Chernow. 1983. Gentamicin-induced hypomagnesemia.. https://pubmed.ncbi.nlm.nih.gov/6638694/

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