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PubMed · 6644346

Changes in immune function in patients receiving natural leukocyte interferon.

A E Maluish·J R Ortaldo·S A Sherwin·R K Oldham·R B Herberman
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Abstract

Highly purified human lymphoblastoid interferon derived from virus-stimulated Namalwa cells was administered daily by 6-h i.v. infusion or i.m. injection to 40 patients with a variety of disseminated malignancies refractory to standard therapy. Each patient received escalating doses of 0.1-50 X 10(6) U for up to 5 weeks. Extensive monitoring for changes in various immune functions revealed no sustained elevation in natural killer cell activity, elevated monocyte-mediated antitumor cytostatic activity in approximately 30% of the patients, and depressed lymphoproliferative responses to mitogens and mixed leukocyte culture.

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Cytotoxicity, ImmunologicHumansInfusions, ParenteralInjections, IntramuscularInterferon Type IKiller Cells, NaturalMonocytesNeoplasmsJournal Article

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A E Maluish, J R Ortaldo, S A Sherwin, R K Oldham, R B Herberman. 1983. Changes in immune function in patients receiving natural leukocyte interferon.. https://pubmed.ncbi.nlm.nih.gov/6644346/

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