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PubMed · 6652613

Nonrandom chromosomal changes in untreated retinoblastomas.

W F Benedict·A Banerjee·C Mark·A L Murphree
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Abstract

The karyotypic patterns of 15 retinoblastomas were examined. Five tumors were found to have two distinct stem lines and, therefore, the chromosomal patterns of 20 tumor cell lines are reported. Three nonrandom chromosomal changes, namely, a loss of a chromosome #13, the presence of an i(6p), or a trisomy of 1q were observed. The potential importance of these chromosomal changes in tumor development is discussed, particularly the loss of a chromosome #13 or the gain of an i(6p). At least one of the three chromosomal changes was found in 75% of the tumor lines analyzed.

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AneuploidyCell LineChromosome AberrationsChromosome DisordersEye NeoplasmsFemaleFunctional LateralityHumansKaryotypingMaleRetinoblastomaJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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W F Benedict, A Banerjee, C Mark, A L Murphree. 1983. Nonrandom chromosomal changes in untreated retinoblastomas.. https://doi.org/10.1016/0165-4608(83)90090-0

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