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PubMed · 6653720

Hypergravity promotes cell proliferation.

A Tschopp·A Cogoli
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Abstract

When HeLa cells, chicken embryo fibroblasts, sarcoma Galliera cells, Friend leukemia virus transformed cells and human lymphocytes are cultured in a hypergravitational field (e.g. 10 X g) proliferation rate is increased by 20-30%, whereas glucose consumption per cell is lower than at 1 X g. Tracking of cell movements on gold-coated substrates reveals that cell migration is hindered at high-g. These findings suggest that under gravitational stress the cell is either capable of shifting to other metabolic pathways and/or consumes less energy at high-g than at 1 X g. This work describes ground-based investigations related to experiments to be performed on future Spacelab missions.

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AnimalsCell DivisionCell LineCell MovementCentrifugationChick EmbryoFibroblastsFriend murine leukemia virusGlucoseGravitationHeLa CellsHumansHydrostatic PressureLeukemia, ExperimentalLymphocytesRatsSarcomaSpace FlightJournal ArticleResearch Support, Non-U.S. Gov't

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A Tschopp, A Cogoli. 1983-12-15. Hypergravity promotes cell proliferation.. https://doi.org/10.1007/bf01990088

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