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A model for differentiation.

I Barrai
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Abstract

A model is proposed, in which differentiation is attributed to colinearity between polymerase states and promotors. The promotors are considered the equal of ordinal numbers, and the state of a polymerase molecule is changed by the activity of the products of the gene it has transcribed. Introns are assumed to be involved in this possibility. Repeated sequences function as labels of chromosomes and chromosome regions, and interact with the diffusing RNA polymerase molecules aimed at a given class of promotors, increasing the speed of specific interactions. The possibility that a quantitative code, with a form of scansion, exists to order promotors as well as repeated sequences, is discussed. A correlation between the base sequence of repeats and promotors is predicted.

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Base SequenceCell DifferentiationColiphagesDNA-Directed RNA PolymerasesGenetic CodeHumansModels, BiologicalMutationOperonProtein BiosynthesisRepetitive Sequences, Nucleic AcidTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov't

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I Barrai. 1983-12-07. A model for differentiation.. https://doi.org/10.1016/0022-5193(83)90182-0

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