[Structural changes in influenza virus RNA during its attenuation].

N N Zhilinskaia; Iu V Kozlov; A G Kurmanova; V I Rumovskiĭ; A A Baev

PubMed · 6656749

[Structural changes in influenza virus RNA during its attenuation].

N N Zhilinskaia·Iu V Kozlov·A G Kurmanova·V I Rumovskiĭ·A A Baev

Abstract

Changes in structures of only two genes of influenza virus--M and NS genes were found during virus attenuation by the method of oligonucleotide mapping. Such changes were observed in virulent and attenuated viruses (passages 10-23 in chick embryos) by comparing intermediate variants of the virus (passages 11-16 in chick embryos). These results allow us to conclude the important role of these genes in virus attenuation and in connection with virulence of the virus.

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Animals Chick Embryo Electrophoresis, Polyacrylamide Gel Genes, Viral Humans Influenza A virus Oligonucleotides RNA, Viral Time Factors Virion Virulence English Abstract Journal Article

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N N Zhilinskaia, Iu V Kozlov, A G Kurmanova, V I Rumovskiĭ, A A Baev. [Structural changes in influenza virus RNA during its attenuation].. https://pubmed.ncbi.nlm.nih.gov/6656749/

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