On constrained balance randomization for clinical trials.

D M Titterington

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PubMed · 6671120

On constrained balance randomization for clinical trials.

D M Titterington

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Abstract

A method is proposed for calculating the probabilities of assignment of a patient to treatments; it involves minimizing a quadratic criterion subject to a balance constraint. The optimal probabilities are very easy to compute. Numerical illustration is given and comparisons are drawn with the entropy-based methods of Klotz (1978, Biometrics 34, 283-287).

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D M Titterington. 1983. On constrained balance randomization for clinical trials.. https://pubmed.ncbi.nlm.nih.gov/6671120/

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