Does cell density correlate with red cell age?

M Morrison; C W Jackson; T J Mueller; T Huang; M E Dockter; W S Walker; J A Singer; H H Edwards

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PubMed · 6675678

Does cell density correlate with red cell age?

M Morrison·C W Jackson·T J Mueller·T Huang·M E Dockter·W S Walker·J A Singer·H H Edwards

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Abstract

We have examined age-related changes in red cells by employing a serial hypertransfusion protocol to generate populations of in vivo-aged mouse red cells. Studies of these old cells have revealed alterations in membrane components; namely, a conversion of band 4.1b to 4.1a and an increase in the amount of membrane-associated, Triton-insoluble globin. Furthermore, we have found that the erythrocyte does change in density, but only during the earliest stages of its life-span. As the cell continues to age, there is no longer a correlation between age and density.

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Animals Blood Circulation Blood Transfusion Erythrocyte Aging Erythrocyte Count Iron Radioisotopes Mice Time Factors Journal Article

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M Morrison, C W Jackson, T J Mueller, T Huang, M E Dockter, W S Walker, J A Singer, H H Edwards. 1983. Does cell density correlate with red cell age?. https://pubmed.ncbi.nlm.nih.gov/6675678/

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