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Tolerance develops to LSD while the drug is exerting its maximal behavioral effects: implications for the neural bases of tolerance.

M E Trulson·T Crisp
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Abstract

Tolerance to a test dose of 50 mg/kg of LSD occurred within 0.5-1.0 h following an initial dose of 10 mg/kg of the drug, using limb flicking and abortive grooming as behavioral indices in the cat. These findings represent an example of very rapidly developing drug tolerance using a behavioral index. These data are discussed within the context of hypotheses concerning the neurochemical bases of tolerance to LSD.

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AnimalsBehavior, AnimalCatsCentral Nervous SystemDrug Administration ScheduleDrug ToleranceFemaleGroomingLysergic Acid DiethylamideMaleJournal Article

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M E Trulson, T Crisp. 1983-12-23. Tolerance develops to LSD while the drug is exerting its maximal behavioral effects: implications for the neural bases of tolerance.. https://doi.org/10.1016/0014-2999(83)90323-0

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