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PubMed · 6685300

Ethanol and dopaminergic systems.

L Lucchi·M Lupini·S Govoni·V Covelli·P F Spano·M Trabucchi
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Abstract

Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the production of cyclic AMP. This finding demonstrates that the dopaminergic receptor associated with adenylate-cyclase activity is affected by chronic ethanol treatment. In particular, the affinity of the dopaminergic receptor labelled by 3H-Spiperone is enhanced. In addition, the receptor-adenylate cyclase coupling system is impaired after chronic in vivo exposure of animals to ethanol.

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Adenylyl CyclasesAlcoholic IntoxicationAlcoholismAnimalsBrainCorpus StriatumDopamineEthanolHumansMaleMembrane FluidityNeuronsRatsRats, Inbred StrainsReceptors, DopamineSynaptic MembranesJournal Article

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L Lucchi, M Lupini, S Govoni, V Covelli, P F Spano, M Trabucchi. 1983. Ethanol and dopaminergic systems.. https://doi.org/10.1016/0091-3057(83)90203-4

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