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PubMed · 6685309

Decrease in ethanol consumption by naloxone in naive and dependent rats.

P Marfaing-Jallat·D Miceli·J Le Magnen
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Abstract

Acute effects of the opiate antagonist, naloxone, on alcohol intake have been examined and compared in naive and behaviorally dependent rats. In naive rats the aversion to an 8% alcohol solution exhibited in a 30 min presentation was selectively augmented by an IP administration of naloxone (1 mg/kg) 30 min before a morning drinking session. In other rats, behavioral dependence was established by 15 days of IG administration of intoxicating doses of alcohol. This dependence was exhibited by a sustained preference for ethanol for 6 days. Naloxone (1 mg/kg) abolishes the acquired preference for ethanol tested during an 8 hour day time presentation. These effects of naloxone on alcohol intake in ethanol naive and dependent rats are interpreted in relation to a general non-specific action of naloxone on preferred or aversive flavoured solutions.

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Alcohol DrinkingAlcohol Withdrawal DeliriumAlcoholismAnimalsAvoidance LearningChoice BehaviorHumansMaleNaloxoneRatsRats, Inbred StrainsTasteJournal Article

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P Marfaing-Jallat, D Miceli, J Le Magnen. 1983. Decrease in ethanol consumption by naloxone in naive and dependent rats.. https://doi.org/10.1016/0091-3057(83)90232-0

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