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Immune inflammation in newly developing facsimile synovia.

Y M Sin·A D Sedgwick·D A Willoughby
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Abstract

The injection of air into the subcutaneous tissue of the back in rodents has previously been shown to induce a lining which closely resembles synovial lining tissue. Air pouches of different ages represent the developmental stages of such tissue. We have found that pouches of 1 day in age induced in animals previously sensitised with bovine serum albumin (BSA) respond with low numbers of infiltrating leucocytes and a small fluid exudate volume 4 h after challenge into the pouch with BSA. In contrast, 3- and 6-day-old pouch tissue when challenged with antigen responds with a greater influx of leucocytes and a larger fluid exudate. These findings suggest that the constituent make-up of the air pouch-lining tissue is important for the full expression of the inflammatory response.

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AnimalsAntigen-Antibody ComplexDisease Models, AnimalExudates and TransudatesMaleRatsRats, Inbred StrainsSynovial MembraneSynovitisJournal ArticleResearch Support, Non-U.S. Gov't

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Y M Sin, A D Sedgwick, D A Willoughby. 1984. Immune inflammation in newly developing facsimile synovia.. https://doi.org/10.1159/000233484

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