PubMed · 6701241
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J A Stern, L C Walrath, R Goldstein. 1984. The endogenous eyeblink.. https://doi.org/10.1111/j.1469-8986.1984.tb02312.x
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Subjective consciousness suggests a unity of the sensing and perceiving self that is difficult to reconcile with the multiplicity of sensory analyzers and the absence of a convergence zone in the brain. This has led--on the one hand--to the dead-end assumption of a unifying sentient homunculus and--on the other--to a denial of conscious unity. The sketchpad model presented here avoids this dilemma by viewing conscious thought as a selfreferent loop of neural activity, rather than as the information content of a fictitious set of output neurons. Use is made of the numerous neural pathways that originate at various cortical and subcortical areas and terminate in the thalamus. The model assumes that primary sensory inputs are modified by such feedback in the thalamic relay nuclei through hill-climbing processes that tend to optimize global responses.
Magnitude-estimation functions for single observers, derived from multiple judgments of closely spaced stimuli, exhibit a sinuous form in logarithmic coordinates, an observation frequently confirmed since first reported by Luce and Mo (1965). We propose that this can result from reliance on a restricted pool of responses, called "preferred numbers" by Baird and Noma (1975). We describe a model featuring a response band centered on an assumed power function, from which the observer selects from among preferred numbers with equal probability. In simulations, the expected values of these selections oscillate around the underlying power function with an appearance similar to that of Luce-Mo functions. The appearance of these functions depends on values assumed for the scale factor of the power function, the range of intensities considered, and the width of the band from which responses are drawn. We conclude that sinuosity in magnitude-estimation functions does not disconfirm the psychophysical power law.
A randomized, double-blind, placebo-controlled trial was conducted to assess the acute effects of placebo and three doses of methylphenidate (MPH) (0.3, 0.6, 0.9 mg/kg) on cognitive flexibility and overt behavior in 28 children with a confirmed diagnosis of attention deficit-hyperactivity disorder. Two underlying cognitive processes (response inhibition and response reengagement) were assessed by measuring the probability and speed with which subjects could inhibit responses to a primary task (forced-choice letter discrimination) and immediately execute a response to a secondary task (simple reaction time) when given a signal to do so. Results indicated that MPH enhanced cognitive flexibility, although the high dose was less effective than lower doses in enhancing response inhibition. Dissociations of dose effects on cognitive function and behavior were demonstrated: Dose-response functions for changes in behavior were linear, whereas the function for response inhibition was U-shaped. Findings argue against the typical clinical practice of determining the response to stimulant treatment from a single measure such as parent report of child behavior.