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PubMed · 6705331

Postnatal new bone formation.

H Nogami·A Oohira
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Abstract

The morphologic events and macromolecular interactions in matrix-induced bone formation are comparable with those occurring in the development of fracture callus. Thus, bone induction by decalcified bone matrix is an experimental model for fracture healing and a new tool for research concerning the biochemistry of bone cell differentiation. Three conditions are necessary for bone cell differentiation in postnatal life: (1) a three-dimensional pattern of proliferation of mesenchymal cells; (2) anchorage-dependent microvilli extending the proliferating cells; and (3) a locally released bone morphogenetic protein (BMP). To date, BMP with a molecular weight of 17,500-18,500 daltons has been isolated from bone, and a BMP-like protein with a molecular weight of 22,000 daltons has been extracted from mouse osteosarcoma. It is difficult to separate BMP, a collagenase-resistant, trypsin-labile acidic polypeptide, from several other low molecular weight proteins.

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AnimalsBone DevelopmentBone and BonesCalcification, PhysiologicCartilageCell DifferentiationCell DivisionCollagenOsteogenesisPeptidesProteoglycansRatsJournal Article

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H Nogami, A Oohira. 1984. Postnatal new bone formation.. https://pubmed.ncbi.nlm.nih.gov/6705331/

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