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Decrease of morphine-induced prolactin release by a procedure causing prolonged stress.

M I Fekete·B Kanyicska·T Szentendrei·A Simonyi·E Stark
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Abstract

The effects of morphine and fentanyl on plasma prolactin levels in rats have been measured. It was found that a prolonged immobilization stressful procedure for 5 h inhibited the response to morphine and fentanyl to increase prolactin secretion, but did not influence the increase in plasma prolactin caused by haloperidol. The injection of a large dose of cortisol (25 mg/kg, s.c.) also evoked an inhibition of morphine-induced prolactin release. The inhibition was maximal 24 h after the administration of the glucocorticoid. These results indicate that stress may induce prolonged alteration in endogenous opioid-mediated neuromodulation via a prolonged release of glucocorticoids.

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AnimalsDepression, ChemicalFentanylHaloperidolHydrocortisoneMaleMorphineProlactinRatsRats, Inbred StrainsRestraint, PhysicalStress, PhysiologicalTime FactorsJournal Article

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M I Fekete, B Kanyicska, T Szentendrei, A Simonyi, E Stark. 1984. Decrease of morphine-induced prolactin release by a procedure causing prolonged stress.. https://doi.org/10.1677/joe.0.1010169

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