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A method for screening diuretic agents in the rat.

S T Kau·J R Keddie·D Andrews
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Abstract

A reproducible screening method for diuretic agents has been developed based upon the selection of a group of homogenous rats with a similar excretory pattern of water and electrolytes. Normal saline (4% body weight) was used as a hydrating fluid to select appropriate rats and to validate the diuretic activity of standard diuretics. The method required only a small number of rats for screening compounds and produced consistent responses in increasing water and electrolyte excretion.

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AnimalsDiuresisDiureticsDrug Evaluation, PreclinicalMaleRatsRats, Inbred StrainsJournal Article

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S T Kau, J R Keddie, D Andrews. 1984. A method for screening diuretic agents in the rat.. https://doi.org/10.1016/0160-5402(84)90054-8

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