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Extracellular ascorbic acid increases in striatum following systemic amphetamine.

J D Salamone·L S Hamby·D B Neill·J B Justice
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Abstract

Push-pull perfusion of the anterior striatum was performed in freely moving rats which were administered 4 mg/kg d-amphetamine sulfate. Ascorbic acid was measured in the perfusate using high performance liquid chromatography with electrochemical detection. Increased extracellular ascorbic acid resulted from the amphetamine, lasting over a period of two hours. The time course of the increase corresponded to the increased oxidation current measured by intrastriatal chonoamperometry under equivalent conditions.

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AnimalsAscorbic AcidChromatography, High Pressure LiquidCorpus StriatumDextroamphetamineElectrochemistryExtracellular SpaceMalePerfusionRatsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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J D Salamone, L S Hamby, D B Neill, J B Justice. 1984. Extracellular ascorbic acid increases in striatum following systemic amphetamine.. https://doi.org/10.1016/0091-3057(84)90311-3

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