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An analytical method to evaluate cooling rates during cryopreservation protocols for organs.

B Rubinsky·E G Cravalho
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Abstract

A simple, graphical procedure has been established to estimate the cooling rates at a specified location and temperature in a biological medium frozen by imposing a constant cooling rate at the outer surface. The graphical procedure also facilitates the determination of the outer surface temperature at the instant a given temperature has been attained in a specific location. The results obtained through a numerical study using finite elements can be applied to biological media with various chemical compositions including different concentrations of cryoprotective agents.

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B Rubinsky, E G Cravalho. 1984. An analytical method to evaluate cooling rates during cryopreservation protocols for organs.. https://doi.org/10.1016/0011-2240(84)90326-2

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