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PubMed · 674187

[Interrelationship between complement activity and the monocytic reaction].

L P Titov
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Complement System ProteinsHemolysisHumansLeukocytesMonocytesNeutrophilsTuberculosis, PulmonaryEnglish AbstractJournal Article

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L P Titov. 1978. [Interrelationship between complement activity and the monocytic reaction].. https://pubmed.ncbi.nlm.nih.gov/674187/

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Enhanced IgG- and complement-independent phagocytosis of sulfatide-enriched human erythrocytes by human monocytes.

Phagocytosis by adherent human monocytes of human erythrocytes (RBC), sulfatide-enriched by incubation with 10(-12) to 10(-9) M cerebroside sulfate, was enhanced approx. 6-fold. Increased phagocytosis was observed only in RBC opsonized with fresh plasma, and not in non-opsonized or serum-opsonized RBC. Increased phagocytosis was immunoglobulin- and complement independent. Thrombospondin and von Willebrand factor, present in plasma but not in serum, and binding selectively to sulfatides, are likely mediators of the enhanced phagocytosis.

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