Age-related decrease in the link-stability of proteoglycan aggregates formed by articular chondrocytes.

A H Plaas; J D Sandy

doi:10.1042/bj2200337

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Age-related decrease in the link-stability of proteoglycan aggregates formed by articular chondrocytes.

A H Plaas·J D Sandy

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Abstract

Chondrocytes were isolated from the articular cartilage of rabbits aged between 6 and 50 weeks and labelled with [35S]sulphate after 48 h in monolayer culture. The percentage of the total proteoglycan monomers synthesized by each culture that were present as link-stabilized aggregates was shown to be about 83% at 6, 9 and 12 weeks, 73% at 15 weeks, 48% at 30 weeks and 32% at 50 weeks. The proliferative activity of the cells in culture also decreased markedly with the age of the donor. The results suggest that aging of chondrocytes in vivo is accompanied by a decrease in their capacity for link-protein synthesis.

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Aging Animals Cartilage, Articular Cell Division Cells, Cultured Macromolecular Substances Proteoglycans Rabbits Journal Article Research Support, Non-U.S. Gov't

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A H Plaas, J D Sandy. 1984-05-15. Age-related decrease in the link-stability of proteoglycan aggregates formed by articular chondrocytes.. https://doi.org/10.1042/bj2200337

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