[Age-related decrease of the binding of isolated rat liver and brain nuclei with glucocorticoid-receptor complexes].

G L Luksha; B F Vaniushin

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PubMed · 6743707

[Age-related decrease of the binding of isolated rat liver and brain nuclei with glucocorticoid-receptor complexes].

G L Luksha·B F Vaniushin

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Abstract

Isolated nuclei from liver and brain of rats of various age bind isolated and 1000-2000-fold purified glucocorticoid-receptor complexes (GRC) containing [3H]dexamethasone. The binding of GRC by the nuclei decreases with an increase in the NaCl concentration from 0 to 0.4 M in a medium. The maximal degree of GRC binding is observed in the liver and brain nuclei of newborn rats (1-day-old); the nuclei of adult animals aged 3 months bind GRC 1/2 times as much. in old (25-month-old) and grown-up animals, no significant differences in GRC binding by nuclei from respective tissues were revealed. Brain nuclei of newborn rats were shown to bind GRC to a greater extent than liver nuclei.

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Aging Animals Brain Cell Nucleus In Vitro Techniques Liver Rats Receptors, Glucocorticoid Receptors, Steroid English Abstract Journal Article

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G L Luksha, B F Vaniushin. 1984. [Age-related decrease of the binding of isolated rat liver and brain nuclei with glucocorticoid-receptor complexes].. https://pubmed.ncbi.nlm.nih.gov/6743707/

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