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PubMed · 6744730

Beta-tricalcium phosphate delivery system for bone morphogenetic protein.

M R Urist·A Lietze·E Dawson
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Abstract

An aggregate of biodegradable beta-tricalcium phosphate and bone morphogenetic protein (BMP/TCP) induces the differentiation of cartilage within eight days, cartilage and woven bone within 12 days, and lamellar bone, including bone marrow, within 21 days. The yield of new bone from a 1-mg dose was more than 12 times greater from the TCP/BMP than from the BMP alone. Whether TCP acts as a slow-release delivery system, potentiates the activity of BMP, or serves to distribute BMP in a favorable three-dimensional pattern requires further investigation.

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AnimalsBiocompatible MaterialsBone MarrowBone Morphogenetic ProteinsCalcium PhosphatesCartilageCattleCell DifferentiationDrug CombinationsGrowth SubstancesHumansMiceMice, Inbred StrainsOsteogenesisProteinsTime FactorsComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M R Urist, A Lietze, E Dawson. Beta-tricalcium phosphate delivery system for bone morphogenetic protein.. https://pubmed.ncbi.nlm.nih.gov/6744730/

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