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Analysis of pharmacokinetic data using parametric models--1: Regression models.

L B Sheiner
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Abstract

This is the first in a series of tutorial articles discussing the analysis of pharmacokinetic data using parametric models. In this article, the purposes of modelling are discussed; regression models for individuals and populations are defined; and structural and variance models are discussed as the two required submodels of the overall regression model. Topics of future articles are: point estimates of parameters; interval estimates of parameters; model criticism and choosing among contending models; population kinetic models and estimation; and elements of optimal design.

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HumansKineticsModels, BiologicalPharmaceutical PreparationsRegression AnalysisJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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L B Sheiner. 1984. Analysis of pharmacokinetic data using parametric models--1: Regression models.. https://doi.org/10.1007/bf01063613

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