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PubMed · 6750476

Cephalothin prophylaxis for midtrimester abortion.

M R Spence·T M King·R T Burkman·M F Atienza
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Abstract

A randomized prospective double-blind study was conducted to determine the efficacy of prophylactic antibiotics as compared with placebo in 198 women undergoing second-trimester intraamniotic injection abortions. Patients received either sodium cephalothin or placebo intravenously before the procedure and for up to 8 additional doses. In 11 patients postabortion endometritis developed; 2 had received the antibiotic and 9 had received a placebo (P less than .05). Prophylactic cephalothin decreased the incidence of endometritis in patients undergoing midtrimester injection abortion. An injection-abortion interval greater than 24 hours appears to identify patients at risk for the development of postabortion endometritis.

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Abortion, InducedAdultCephalothinClinical Trials as TopicDouble-Blind MethodEndometritisFemaleHumansPregnancyPregnancy Trimester, SecondPremedicationClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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M R Spence, T M King, R T Burkman, M F Atienza. 1982. Cephalothin prophylaxis for midtrimester abortion.. https://pubmed.ncbi.nlm.nih.gov/6750476/

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