PubMed · 6754248
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
J Gille. 1982. Immunopathological alterations in the dysfunctioning placenta.. https://pubmed.ncbi.nlm.nih.gov/6754248/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Periventricular heterotopia (PH) involves dramatic malformations of the human cerebral cortex. Here we show that PH is closely linked to markers in distal Xq28 (maximal two-point lod score = 4.77 for F8C at theta = 0; maximal multipoint lod score = 5.37), so that affected females are obligatory mosaics for the mutation; that PH is lethal to at least some affected males; that PH malformations consist of well-differentiated cortical neurons filling the adult subependymal zone; and that individuals with PH are at high risk for epilepsy, though they have no other neurological or external stigmata. The PH gene may represent an important epilepsy susceptibility locus in addition to playing a key role in normal cortical development.
Explore the source record for details and available documents.
In mammals, reproduction involves two potentially incompatible mechanisms: viviparity and development of a competent immune system. Thus the maternal and foetal organisms must respond by developing immunologic tolerance. The phenomenon does not involve total immunosuppression, but includes several highly precise processes initiated at conception. It is known that cell- and humour-mediated processes occur but their relative importance remains to be elucidated. Cytokines, especially those mediating T-helper2 cell response appear to play a predominant role in inducing immunologic tolerance to the foetal allograft. A better understanding of these mechanisms could have major implications in the diagnosis and treatment of repeated miscarriage and unexplained infertility.