Monoamine oxidase substrates and substrate affinity.

E F Domino

doi:10.1093/schbul/6.2.292

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Monoamine oxidase substrates and substrate affinity.

E F Domino

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Abstract

The evidence that there are two forms of monoamine oxidase (MAO) enzymes is reviewed. On the basis of various substrate affinities, differential inhibition by deprenyl and clorgyline, and heat inactivation, there appear to be a type A and a type B MAO in various tissues. The enzymatic oxidation of telemethylhistamine (tMH) is an example of an endogenous substrate for type B MAO.

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Animals Biotransformation Cerebral Cortex Clorgyline Histamine Hypothalamus Isoenzymes Molecular Conformation Monoamine Oxidase Monoamine Oxidase Inhibitors Rats Selegiline Substrate Specificity Journal Article

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E F Domino. 1980. Monoamine oxidase substrates and substrate affinity.. https://doi.org/10.1093/schbul%2F6.2.292

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